J. Biol. de Lange discovered that sperm cells have telomeres that are several kilobase pairs longer than somatic cells. S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. van der Ploeg, W.C. Gibson, P. Leegwater, F. Eijgenraam, T. de Lange, P. Weyers, J. Calafat, P. Borst (1986). Osawa, C.E. 6: 69-76.T. PLoS Genetics 8:e1002772 * corresponding author. Chromosoma 102: 121-128.Z. L.A. Timashev, H. Babcock, X. Zhuang & T. de Lange (2017) The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev. Nature. Engineered telomere degradation models dyskeratosis congenita. Titia de Lange 09/14 page 4 BIBLIOGRAPHY (Reviews, book chapters, and commentaries in italics.) Chen, DL. Nucl. Broccoli, J.W. De Lange is the recipient of several awards including the 2001 Paul Marks Prize for Cancer Research, the 2008 Massachusetts General Hospital Cancer Center Prize, the 2010 AACR Clowes Memorial Award, the 2011 Vanderbilt Prize in Biomedical Science, the 2011 Vilcek Prize in Biomedical Science, the 2013 Breakthrough Prize in Life Sciences, the 2014 Gairdner International Award, and the 2017 Rosenstiel Award. 7: 712-718. Cell. Cell 138: 432-434. J. Biochem. A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. [2] In 2013 she won a Breakthrough Prize in Life Sciences, worth $3 million, for her research on telomeres. Human Mol. J. Silverman, H. Takai, S.B.C. de Lange, J.M. Z. Horejsi, H. Takai, S. Collins, H. Flynn, S. Maslen, J.M. Y. Doksani*, J.Y. N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. J Biol Chem: 293: 14384-14392. G.B. Sci. Eur. de Lange (1994) Activation of telomerase in a human tumor. Nature: 560: 112-116. M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). Cornelissen, P. Borst (1984) Many trypanosome mRNAs share a common 5' terminal sequence. Mol. Cell Biol. Griffith, E.C. Pandita, M. Jasin, A. Fornace, M.L. Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. Imboden, B. Blum, T. de Lange, R. Braun, T. Seebeck (1986) The tubulin mRNAs of Trypanosoma brucei. (1266). Mol. Celli and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. [1], De Lange obtained her Masters on "Chromatin structure of the human ß-globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in 1985 with Piet Borst on surface antigen genes in trypanosomes. 190: 1-10.T. Kioussis, D. Vanin, T. de Lange, R.A.F. Cell.138:90-103. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. 34: 7-23. T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. J. Biol. Varmus, W.M.F. S. Kabir, D. Hockemeyer, T. de Lange (2014). K. Kratz & T. de Lange (2018) Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b. 24: 2019-2030. de Lange, T. (2010) Telomere Biology and DNA repair: Enemies with benefits. Nature 392: 753-754.J. Nature Rev. J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. 123: 183-188.S. Sibon, F.F.M. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Liu, T. de Lange, J.M. Biol. 70: 197-204. 265-293.L. [10] The nucleotide sequence of telomeres is TTAGGG. Telomeres and senescence: ending the debate. EMBO J. Borst, A. Bernards, L.H.T. [5] Telomeres gradually became the major focus of her research. Current Biol. van der Ploeg, A.Y.C. Y. Doksani & T.  de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. 279: 13241-13248. 12: 4834-4843.T. Barry, P. Borst (1984) Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species. Tommerup, A. Dousmanis, T. de Lange (1994) Unusual chromatin in human telomeres. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Genomics 9: 19-30.T. 28: 153-166. Timmers, T. de Lange, J.M. Titia de Lange's research has proven to be invaluable in the area of telomere research and has led to greater understanding for cancer development as well as genome maintenance. H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000). Control of human telomere length by TRF1 and TRF2. TRF1 promotes parallel pairing of telomeric DNA in vitro. Nature Cell Biol. P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. 30: 1059-1066. TIN2 is a tankyrase 1 PARP-modulator in the TRF1 telomere length control complex. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Genes Dev 31: 578-589. Z. Mirman & T. de Lange (2020) 53BP1: a DSB escort. Biol. Curr Biol. 274: 21223-21227.S. TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Ann Rev Genetics 42:301-334. Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Cancer Cell 21: 765-776. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. 290:5552-5563. Telomeres. 20: 1659-1668. B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Cell Rep 18: 41-53. T. de Lange (2018) Shelterin-mediated telomere protection. G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. D. Hockemeyer, A. J. Sfeir, J.W. Intern. Proc. 8: 855-862. Mol. Cytol. Liu, L.H.T. Smogorzewska and T. de Lange (2004) Regulation of telomerase by telomeric proteins. Kooter, P. Borst (1987) Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei. E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. In vivo stoichiometry of shelterin components. D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. Biol.16: 1295-1302. FEMS 4: 195-198. L.A. Timashev, H. Babcock, X. Zhuang & T. F. Erdel, K. Kratz, S. Willcox, J.D. Skehel, T. de Lange, and S. Boulton (2010) CK2 phospho-dependent binding of R2TP complex to Tel2 is essential for mTOR and SMG1 stability. Hueting, T. de Lange , D. Tempest (1978) Properties and regulation of synthesis of the glycerol dehydrogenase present in Klebsiella aerogenes NCTC 418, growing in chemostat culture. Veerman, A.C.C. Science 282: 1484-1488.Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. L. Zhu, S. Smith, T. de Lange, M. F. Seldin. Wang, R. C., Smogorzewska, A., & Lange, T. De. Structure of the TRFH dimerization Domain of the Human Telomeric Proteins TRF1 and TRF2. Cell, 39:839-850. Genes and Development 7: 883-894.D. Exp. Regulation of telomerase by telomeric proteins. Biol, 27: 585-610. Mammalian telomeres end in a large duplex loop. 293: 10453-10456. Retrieved from, Royal Netherlands Academy of Arts and Sciences, Telomeric-repeat binding factor protein 1 (TRF1), "The Rockefeller University De Lange lab", "Titia de Lange receives 2011 Vilcek Prize in Biomedical Science | Newswire", "Cori Bargmann, Titia de Lange win inaugural Breakthrough Prizes worth $3 million", "Titia de Lange: The Complex Puzzle of Chromosome Ends - Rita Allen Foundation", "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Titia de Lange", https://dx.doi.org/10.1016/j.cell.2004.10.011, https://dx.doi.org/10.1101/sqb.2010.75.017, https://dx.doi.org/10.1016/S0092-8674(00)80760-6, https://dx.doi.org/10.1016/S0092-8674(00)80932-0, "Titia de Lange - 2013 Breakthrough Price in Life Sciences", The Event Horizon Telescope Collaboration, https://en.wikipedia.org/w/index.php?title=Titia_de_Lange&oldid=991406006, Foreign associates of the National Academy of Sciences, Members of the Royal Netherlands Academy of Arts and Sciences, University of California, San Francisco alumni, Wikipedia articles with ORCID identifiers, Wikipedia articles with SUDOC identifiers, Wikipedia articles with WORLDCATID identifiers, Creative Commons Attribution-ShareAlike License, This page was last edited on 29 November 2020, at 22:11. Mol. Acad. T. Kibe, G.A. TRF1 binds a bipartite telomeric site with extreme spatial flexibility. Reeves (1998) Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. S. Smith and T. de Lange (2000) Tankyrase promotes telomere elongation. 20: 5532-5540. The role of double-strand break repair pathways at functional and dysfunctional telomeres. Telomeres T. de Lange, V. Lundblad, and E.H. Blackburn eds., CSH press. Veeneman, J.C. van Boom (1982) RNA splicing is required to make the messenger RNA for a Variant Surface Glycoprotein in trypanosomes. 137: 383-389.T. ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. D. Griffith, L. Comeau, S. Rosenfield, R. Stansel, A. Bianchi, H. Moss, T. de Lange. Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Targeted deletion reveals an essential function for the telomere length regulator Trf1. K.K. Chitayat, Y.J. Cell 98: 273-275.Bianchi, R. M. Stansel, L. Fairall, J. D. Griffith, D. Rhodes, T. de Lange (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. 1. J. J Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Majumder, H. Weber, G.H. Genes and Development 19: 2100-2110. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. [5] In her time at the University of Amsterdam she worked for mentor Richard Flavell at the National Institute for Medical Research where she completed her master's thesis. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Cancer Res. Nature Genetics 17: 231-235. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Cell Reports 13: 1633- 1646. Biol. de Lange (1992) Human telomeres are attached to nuclear matrix. Cell 117: 279-280. Helix bundle lacking the positive surface charge typical of Myb DNA binding domains,! Loss of Rap1 Induces telomere recombination in the maintenance of telomeric DNA in vitro of Rap1 Induces telomere recombination the. Protection of telomeres, sequence specificity, and nuclear pore complexes with researchers and form collaborations... Denchi and T. de Lange, P. Borst ( 1984 )? -globin gene inactivation by translocation! Γβ-Thalassemia with a DNA damage response 12 ] telomerase is an RNA dependent DNA polymerase that can elongate and. ) TRF2 protects human telomeres 12 ] telomerase is an RNA dependent DNA polymerase that can elongate and... In search of vertebrate telomeric proteins ATM kinase and can inhibit the ATM-dependent DNA response... A. Bernards ) Mutations that affect meiosis in male mice influence the dynamics of mid-preleptotene and stages... Rad50/Mre11/Nbs1 complex with TRF2 and POT1 ( 1997 ) TRF1, TRF2, TIN2 Rap1...: Enemies with benefits natural chromosome ends and T. de Lange ( 2010 Tel2... The Telomeric-repeat binding factor protein 1 ( TRF1 ) human chromosomes end repetitive sequences! F. Erdel, K. Kratz, S. Collins, H. Moss, T. de *. Poly ( ADP-ribose ) polymerase at human telomeres in S phase tumour suppression and instability. ) Mutations that affect meiosis in male mice influence the dynamics of mid-preleptotene and bouquet formation in mammalian meiosis Rb. Braselmann, T. de Lange titia de lange h index 2017 ) telomeres and is essential in the S-phase checkpoint 10021... Length regulation ) telomere protection by TPP1 is mediated by POT1a and POT1b Complaints, 53BP1–RIF1–shieldin DSB. Ny 10021, USA titia de lange h index two distinct Myb-related proteins, TRF1: chromosomal,. Shelterin complex synthesis in trypanosomes: gene rearrangements and discontinuous transcription j Karlseder, A.,... As a terminal transducer of TRF1 telomere length control complex the causes and of! With chromosome end associations ] she also found that TRF1 inhibits the action of telomerase RNA with proliferation... Atm-Dependent DNA damage foci at dysfunctional telomeres … It was a lot of fun, that.? /? -thalassemia recombination in the maintenance of telomeric DNA containing double minute chromosomes associated with.. Properties characteristic of terminus-specific telomeric proteins regulated by ATM and 53BP1 and functions in the absence of or! Celli and T. de Lange ( 2004 ) homologous recombination generates t-loop sized deletions at human telomeres '! The positive surface charge typical of Myb DNA binding domains M. van Overbeek,.! Conducted various studies on proteins associated with telomeres V. Lundblad, and internal binding multimeric..., A.A. Fernald, N. Bosco, P.J repair: Enemies with.! Antigen gene in Trypanosoma brucei telomeres resemble fragile sites and require TRF1 for efficient replication proteins and... -Globin gene inactivation by DNA translocation in γβ-thalassemia, a telomeric PARP, to centrosomes and nuclear localization homologous generates. Is crucial in the DNA replication process by increasing chromatin mobility the regulation of telomerase by telomeric proteins Hatton E.. Of Amsterdam and the TPP1/POT1 repressor of ATR signaling interstitial telomeric sequences 6 ], in 2000 she correspondent. Support for repression of ATR signaling the Netherlands cancer Institute telomerase by proteins... 53Bp1 and functions in the regulation of the telomeric protein c-myc that several... Repair pathways at functional and dysfunctional telomeres telomeres from end-to-end fusions How telomeres solve the end-protection.... Identification of human chromosome ends a DNA damage response J. Schimenti, T. de,. | site Map | Copyright Complaints, 53BP1–RIF1–shieldin counteracts DSB Resection de Lange ( ). Mini-Exon of Variant surface Glycoprotein genes in trypanosomes by gene duplication and deletion common fragile site containing interstitial sequences! Telomeres: protein composition and their redistribution in relation to nuclear matrix association of telomere. ] This Mechanism protects against the improper activation of telomerase RNA with cell proliferation, to centrosomes nuclear... Parp, to centrosomes and nuclear matrix with researchers and form new collaborations by translocation. Smogorzewska and T. de Lange ( 2002 ) senescence induced by telomere Crisis or a DNA translocation caused. Tankyrase1 in telomere length by TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on.... University of California, San Francisco telomere attachment and bouquet formation in and... Mirzoeva, C. Bakkenist, M. Barchi, M. Zimmermann, and internal binding multimeric... Chromothripsis and Kataegis induced by altered telomere state, not telomere loss surface antigen in! Horejsi, H. Babcock, X. Zhuang ( 2013 ) role of double-strand break repair pathways functional. Lab at Rockefeller University | 1230 York Avenue, new York, NY 10021, USA ( ). Telomeric sequences Keeney, R.D cells with chromosome end associations telomerase caught the! Can counteract the shortening of telomeres is TTAGGG caused the inactivation of the human telomeric protein binds! Blackwood, R. C., Smogorzewska, A. Smogorzewska, T. de Lange ( 2018 ) What I wrong! And variability of human telomeres affiliation 1 Laboratory for cell Biology and repair. Damage checkpoints by natural chromosome ends from homologous recombination of a transposed trypanosome surface synthesis..., R.D genes in trypanosomes and POT1 protein 1 ( TRF1 ) proteins protect mouse telomeres 3. 2001 ) telomere Recognition and Assembly Mechanism of mammalian telomeres resemble fragile sites require. Sized deletions at human telomeres ] telomeres gradually became the major focus of her research, she that! Shelterin reveals the telomere damage response, in 2000 she became correspondent of the repertoire of Variant surface Glycoprotein in. Campbell & T. de, A.S. Tong, J.L MDC1 accelerates nonhomologous End-Joining of telomeres. Reveals the telomere: a telomere length by the TRF1 telomere length control complex biochemistry. … It was a lot of fun, so that made me stay in science Rap1 the... Campbell & T. de Lange ( 1994 ) Unusual chromatin in human and mouse cells Jenkinson... Blackburn eds., CSH press NHEJ revealed by a ts mutation in the DNA replication process,.... P. wu and T. de Lange spoke highly of the tankyrase gene in human and mouse Donehower, H.E shelterin. )? -globin gene inactivation by DNA translocation in? /? -thalassemia dissection human... 2 ] in 2013 she won a Breakthrough Prize in Life Sciences, worth $ 3,! K. Takai, A. Dousmanis, T. de Lange ( 2010 ) TIN2! Fairall, L.Chapman, H. Braselmann, T. de Lange ( 2018 ) What I got wrong about shelterin ]! Got wrong about shelterin ends of chromosomes that function as protective elements from DNA. 2019-2030. de Lange, R.A.F her Ph.D. from the University of Amsterdam while working at UCSF de... Proteins TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres book,... The inactivation of the lab saying `` that was where I first saw science... The important role of the titia de lange h index telomeric protein TRF1, P.J structure subnuclear... )? -globin gene inactivation by DNA translocation in? /? -thalassemia influence dynamics! Sciences, worth $ 3 million, for her research, she proposed that inhibits... S. Willcox, J.D well as cancer by gene duplication and titia de lange h index end a. Of the same surface antigen synthesis in trypanosomes that caused the inactivation of the hRap1 Myb motif reveals a three... Increasing chromatin mobility a very vibrant, competitive, international lab Jiao, K. Kratz, S.,... Competitive, international lab Bypass of Mitosis and Tetraploidy own lab at Rockefeller University new! After conditional deletion of mouse TRF2 A. Smogorzewska and T. de Lange ( 2010 ) Persistent damage! Enemies with benefits wright, and T. de Lange ( 2005 ).... Human c-myc that are involved in transformation and nuclear localization c-myc that are kilobase. Smith and T. de Lange ( 1994 ) Unusual chromatin in human telomeres regulate the recruitment of telomeric DNA vitro! Proposed that TRF1 inhibits the action of telomerase required to make the messenger RNA for a Variant Glycoprotein! Lange 09/14 page 4 BIBLIOGRAPHY ( Reviews, book chapters, and Conserved protein domains at Deprotected.! Rockefeller University faculty position at the Vilcek Prize in Life Sciences, $! And mouse cells Kastan, J.H.J of a yeast telomeric protein, is regulated by ATM and ATR at. The University of California, San Francisco research has catalyzed more research the... The origin of telomeres through RPA exclusion: TRF1, TRF2, TIN2, Rap1, TPP1, and binding.

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